March 13, 2025

GeneDx (Nasdaq: WGS), a leader in genomic insights, has introduced Multiscore, an AI-powered gene ranking tool designed to enhance genetic analysis by prioritizing relevant genes more efficiently. This cutting-edge decision support tool aims to streamline workflows, improve diagnostic accuracy, and reduce turnaround times for genetic interpretation.

Revolutionizing Genetic Interpretation with AI

Multiscore leverages GeneDx’s proprietary dataset, publicly available genomic data, and advanced artificial intelligence (AI) algorithms to rank genes based on their alignment with a patient’s clinical presentation. Unlike traditional methods that rely solely on textbook disease descriptions, Multiscore integrates phenotypic similarities, ensuring more accurate and efficient identification of pathogenic or likely pathogenic diagnoses, even in complex cases.

Key Benefits of Multiscore

✔ Enhanced Diagnostic Accuracy: AI-driven gene ranking helps clinical geneticists focus on the most relevant genes, improving diagnostic precision. ✔ Faster Turnaround Time: By automating gene prioritization, Multiscore reduces the need for manual review, accelerating the diagnostic process. ✔ Scalability and Efficiency: Embedded within GeneDx’s interpretation platform, Multiscore offers a seamless and scalable solution for clinical analysis. ✔ Continuous Learning: The tool evolves with every test, enriching GeneDx’s database of 750,000 clinical exomes and genomes and over six million phenotypic datapoints.

Showcasing at ACMG Annual Meeting

Multiscore will be featured at the American College of Medical Genetics and Genomics (ACMG) Annual Meeting in a highly anticipated platform session titled: Multiscore, a Gene Ranker Powered by Artificial Intelligence and Real-World Clinical Data, Shows High Sensitivity in 10,000 Exomes and Genomes.

Bryan Dechairo, PhD, Chief Operating Officer at GeneDx, emphasized the company’s commitment to leveraging AI for large-scale genomic analysis: “Multiscore is just one of the many ways we’re integrating AI into our workflows to drive efficiencies, accelerate diagnoses, and improve patient outcomes.”

Pioneering the Future of Genomic Medicine

As AI continues to redefine precision medicine, GeneDx’s Multiscore tool represents a significant advancement in clinical genomics. By combining AI innovation with extensive real-world genetic data, GeneDx is paving the way for faster, more effective, and scalable genetic diagnostics, ultimately enhancing patient care on a global scale.

For more information, visit www.genedx.com.